ABSTRACT
BACKGROUND Anti-tuberculosis drugs are thought to account for about 50% of drugs that cause liver injury in India. We show that the spectrum of drugs is much wider than previously reported. METHODS We evaluated all patients with unexplained acute liver injury presenting during 2006–2016 using a structured proforma for drug-induced liver injury (DILI). The Roussel Uclaf Causality Assessment Method was used to assess causality. RESULTS DILI was found in 143 of 2534 patients with acute liver injury. Nineteen patients had probable ayurvedic DILI. The other common causes of DILI were statins (16 patients) and anti-tuberculosis drugs (11 patients). Eight patients had DILI post-liver transplant. Fluconazole was the most common cause of post-liver transplant DILI. Chronic DILI (abnormal liver function test after 12 months of stopping the suspected drug) was found in 2 patients. CONCLUSION In otherwise unexplained acute liver injury, DILI due to ayurvedic drugs should be sought. DILI should be considered in post-liver transplant patients. Patients with DILI should be monitored for at least 12 months to exclude progression to chronic DILI.
ABSTRACT
A 2½-year-old boy presented with pruritus and jaundice of 2 weeks duration. On investigation, serum total bilirubin was 23.4 mg/dL and gamma glutamyl transpeptidase was normal. Liver biopsy was consistent with progressive familial intrahepatic cholestasis (PFIC). A partial external biliary diversion (PEBD) was done. Pruritus disappeared, growth improved and serum total bilirubin became normal, 2 months after surgery. This is the first report from India, of PFIC treated with PEBD and suggests that PEBD should be considered in patients with PFIC even if bridging fibrosis is present.
ABSTRACT
BACKGROUND: Crohn's disease is increasingly encountered in India. This paper reviews our experience with surgery for small bowel involvement in Crohn's disease. METHODS: Retrospective analysis of prospectively collected data of patients who underwent surgical resection for Crohn's disease during a period of 8.8 years from 1997-2006 at a tertiary care center. RESULTS: Twenty-eight patients (mean age 31.2 years; 18 men) underwent surgical treatment for Crohn's disease. The diagnosis was made only after surgery in 17 patients; 5 of them were receiving anti-tuberculosis treatment. The most common indication for elective surgery was subacute intestinal obstruction (n=15) followed by enterocutaneous fistula (3) and protein-losing enteropathy (2). Emergency surgery was performed in 4 patients who presented with perforation and peritonitis. Resection of the maximally involved segment and primary anastomosis was done in all elective cases. Resection and exteriorization of resected ends was done in patients who presented with peritonitis. Multiple strictureplasties combined with resection were done in 9 patients. Predominant colonic involvement was observed in 2 patients. The type of small bowel involvement included strictures (n=25), fistulizing disease (8) and perforation (6); 11 patients had more than one pathology. Postoperative morbidity was observed in nine patients; 6 patients underwent re-operation for anastomotic leak. Stoma had to be created in 11 patients either primarily or at re-operation, which could be closed after a median interval of 3.2 months. During a median follow up of 29 months, 3 patients required more than one hospital admission for abdominal symptoms. Pre-operative anemia, malabsorption and/or growth retardation, steroid and/or immunosuppressant therapy and mid small bowel resection had a negative impact on anastomotic integrity leading to anastomotic dehiscence. Indication for surgery, the type or extent of disease did not have any impact on postoperative morbidity. CONCLUSION: This retrospective analysis from a tertiary referral center indicates that sub-acute intestinal obstruction and perforation-peritonitis were the most common indications for surgery in Crohn's disease. Pre-operative anemia, malabsorption state, steroid/immunosuppressant and mid small bowel resection were associated with higher postoperative morbidity.